Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.

DNA topo II:5 μM

Suramin 在培养的HeLa细胞中抑制细胞增殖和DNA合成。40 μM suramin 完全抑制了SV40 DNA的复制。与DNA聚合酶δ（IC50=36 μM）相比，DNA聚合酶α对较低浓度的suramin更敏感（IC50=8 μM），而DNA聚合酶β对该化合物相对不敏感（IC50=90 μM）[1]。Suramin是细菌RecA蛋白DNA链交换和ATP酶活性的强效抑制剂。Suramin抑制RecA催化的LexA抑制因子的蛋白水解切割。Suramin的抑制作用机制涉及其瓦解RecA-单链DNA丝的能力[2]。Suramin是核酶DNA拓扑异构酶II的强效抑制剂。Suramin抑制纯化的酵母拓扑异构酶II，其IC50约为5 μM[3]。

与对照组大鼠相比，经Suramin处理后第21天的肺动脉压力、右心室肥大以及远端血管肌化指标均有所降低。Suramin的治疗能够抑制PA-SMC的增殖，并减轻炎症反应与胶原蛋白的沉积[4]。

The ATPase assay is performed in a 10 μL reaction mixture containing 20 mM Tris-HCl (pH 7.5), 1 mM DTT, 8 mM MgCl2, 5 μM M13 circular ssDNA, 2.5 μM RecA from the specified bacterial species and increasing concentrations of suramin. The reaction is initiated by the addition of 2 mM [α-32P]ATP, incubated for 30 min at 37°C and stopped by the addition of 25 mM EDTA[2].